TRT Side Effects: What to Expect and What's Normal (2026)
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■ TL;DR — The Short Answer Most TRT side effects are mild and manageable. The most common are acne (15-25% of men), elevated hematocrit (the key safety marker — keep under 54%), testicular atrophy (preventable with HCG), and temporary water retention and mood fluctuations. The 2023 TRAVERSE trial found no increased cardiovascular risk, and the FDA removed its black-box warning in 2025. Regular blood work every 3-6 months is non-negotiable. Most TRT side effects are manageable and temporary. The most common issues — acne, water retention, and mood fluctuations — typically resolve within the first few weeks as your body adjusts. Serious side effects are rare with proper monitoring. Here’s what you need to know.